Application of functional imaging techniques to animal models is vital to understand pain
mechanisms, but is often confounded by the need to limit movement artefacts with
anaesthesia, and a focus on evoked responses rather than clinically relevant spontaneous
pain and related hyperalgesia. The aim of the present study was to investigate the potential
of manganese-enhanced magnetic resonance imaging (MEMRI) to measure neural
responses during on-going pain that underpins hyperalgesia in pre-clinical models of …